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Internship 2017-2018

  • Pathogenic shift of host cells exposed to the Cytolethal Distending Toxin – modelization through a Meta-OMIC approach.
  • Epigenetic modifications associated with immunoglobulin gene rearrangements
  • Structural Studies of Kinesin-1 : Regulation and Functions
  • Role of cardiac autonomic afferent fibers in the heart-to-brain axis
  • Regulation of Cav1.2 and Cav1.3 calcium channels in Th2 lymphocytes
  • Le métabolisme des ARN chez les Archées: Caractérisation biochimique du complexe multiprotéique impliquant la Ribonucléase β-CASP aRNase J et l’ Hélicase à ARN aSki2b
  • Molecular dissection of functional amyloid assembly and plasticity in signaling processes
  • Structural, evolutionary and functional investigation of fungal virulence effectors
  • Effect of phosphorus-based dendrimers on Redox metabolism
  • Structural and functional analysis of the transfer of HIV-1 from T lymphocytes to macrophages
  • Molecular bases and functional consequences of mycobacteria recognition by the C-type lectin Dectin-1
  • Studies of multiprotein complexes involved in ribosome biogenesis and linked to human.
  • Identification of key immunomodulatory lipids of Mycobacterium tuberculosis released within extracellular vesicles
  • Role of adipocyte exosomes in tumor progression: Impact of obesity
  • Development of new lipidomic sample preparation
  • 31P NMR as a tool for metabolic analysis
  • Metabolomics approach to evaluate the effectiveness ofnew aquaculture feedstuffs in the seabass
  • Structural study of the intrinsically disordered yeast protein Knr4, isolated or involved in protein complexes with kinases
  • 13C-NMR based fluxomic and 31P NMR of intracellular metabolites
  • Molecular basis and therapy of a mitochondrial-linked optic neuropathy
  • Chemo-enzymatic routes to access Shigella flexneri antigenic oligosaccharides for vaccine development: Biochemical and structural characterization of computationally designed carbohydrate-active enzymes
  • Study of the biophysical membrane mechanisms of lipidic virulence factors of Mycobacterium tuberculosis
  • Study of the effect of modified lipids on the membrane organization of T-cells and HIV infection
  • Demonstration that peptidylarginine deiminases type 1 and type 3 play a major role in human keratinocytes.
  • Dynamic regulation of the glyoxylate shunt in E. coli
  • Semi-rational design of new TB drugs based on the understanding of thecatalytic mechanism of a crucial glycosyltransferase for pathology
  • Structural and functional characterization of M. tuberculosis FAS-II system
  • Interactome and cell signaling of cell polarity proteins
  • Characterization of the mycobacterial lipids presented by CD1b molecules
  • Development of an inhibitor of MITF
  • Characterisation of TIM23 complex (Translocase of the mitochondrial Inner membrane) to tackle protein sorting in mitochondria
  • Interactome analysis of the bacterial envelope-assembly machineries:biogenesis and remodelling programs in bacterial pathogens
  • Mass spectrometry analyses and activity measurement of peptides produced by symbiotic and pathogenic fungi
  • Cryo-EM study of the small ribosomal subunit assembly
  • NMR structure determination
  • Caractérisation protéomique structurale et fonctionnelle de l’enzyme humaine HSulf, une enzyme clé dans la régulation de la sulfatation de l’haparane sulfate
  • Recherche et caractérisation structurale par spectrométrie de masse d’oligosaccharides sulfatés dérivés de l’héparane sulfate, biomarqueurs dans la maladie neurodégénérative mucopolysaccharidose de type III (syndrome de Sanfilippo)
  • Crystal structure determination of the EntD phosphopantetheinyl transferase from extra-intestinal pathogenic isolates of Escherichia coli
  • Structural and functional study of the Mycobacterium tuberculosis FAS-II dehydratase
  • High-resolution 3D structure determination of Pks13, the condensase of mycolic acids, by single-particle cryo-electronmicroscopy
  • Glucocorticoid regulation of a novel pathway controlling T-celltrafficking during inflammation : how is it impared with ageing ?
  • Comparing the association of PA28αβ and PA28α to standard and immuno 20Sproteasome by structural mass spectrometry approaches
  • Spatial organization and dynamics of Mycomembrane-lipids in the cell wall of Mycobacterium smegmatis : a solid state NMR study
  • Structural and functional studies of protein complexes involved in ribosome biogenesis
  • Molecular modelling of protein/surfactant interactions for the understanding of membrane protein stabilizationand crystallization.
  • Approche Métabolomique non ciblée pour l’étude de la Mortalité des Moules
  • Développement des stratégies analytiques innovantes par UPLC couplée à la spectrométrie de masse sur de nouvelles cibles analytiques.
  • Développement d’un couplage électrophorèse capillaire- spectrométrie de masse pour la caractérisation des antigènes vaccinaux
  • Caractérisation par spectrométrie de masse (MS) de biomolécules d'intérêt en oncologie (anticorps, antibody drug conjugates, immunocytokines, scaffolds).
  • Etude de la composition de la matrice du biofilm chez Legionella pneumophila
  • Aspects nanotoxicologiques dans le développement de nanogels anti-inflammatoires à visée thérapeutique – Application à l’arthrose expérimentale
  • Lipidomique ciblée : évaluation de l’impact de contaminants émergeantssur le profil en isoprostanoïdes de mollusques lamellibranches marins
  • Aspects nanotoxicologiques dans le développement de nanogels anti-inflammatoires à visée thérapeutique – Application à l’arthrose expérimentale
  • Développement d'une approche métabolomique pour identifier des métabolitesfongiques létaux pour les adventices

Last updated June 15, 2018

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